Composition generating hydrogen

ABSTRACT

There is provided an external-use composition that is incorporated with a hydrogen storing metal alloy keeping the hydrogen and generating the hydrogen, and that has the antioxidant effect, anti-inflammation effect and antiallergic effect. 
     There is provided a skin external-use composition that is incorporated with a fine particle of hydrogen storing alloyed metal, such as magnesium hydride.

This application is the national phase under 35 U.S.C. §371 of PCTInternational Application No. PCT/JP2011/053891which has anInternational filing date of Jun. 16, 2011 and designated the UnitedStates of America.

FIELD

The present invention relates to a skin external-use composition that isincorporated with a metal or metal alloy storing hydrogen showing theantioxidant effect, anti-inflammatory effect and antiallergic effect andthat generates hydrogen.

BACKGROUND

It is known that a molecular hydrogen (represented by H₂ the chemicalformula) has the antioxidant effect. Thus, the molecular hydrogen isexpected to have advantage for the health enhancement and thetherapeutic and preventive effects to several diseases. Furthermore, itis known that the molecular hydrogen has the anti-inflammatory effectand the antiallergic effect. Moreover, it is shown that the molecularhydrogen has the age registering effect, such as to reduce skinwrinkles.

Water, drinking water, and cosmetics in which the molecular hydrogen issolved are available in the market and are widely utilized. However, itis inconvenient to carry the hydrogen gas cylinder or liquid solution inwhich the molecular hydrogen is dissolved. In addition, the safetyviolation of burning or exploding may cause when much of hydrogen gas isutilized or much of molecular hydrogen is generated. Even if the actualdensity of hydrogen is too low to cause such a safety violation, theutilization of hydrogen gas cylinder or liquid solution may be rejectedin view of the security.

In the case of skin lotion including molecular hydrogen and applied toskin, the hydrogen gas is evaporated. Thus, much of the molecularhydrogen goes out of the skin, i.e., goes to the atmosphere, withoutgoing into the skin. Therefore, it is difficult to keep the molecularhydrogen for a long time, and thus the significant effect can't be notexpected.

The blackness of skin due to the sunspot, freckle, scar and the like iscaused by the melanin, and thus the inhibitor of melanin synthesis isutilized for the whitening cosmetics. However, the strong reducing agentis required for directly reducing the melanin to perform the lightning.Thus, it is difficult to directly perform the lightning of melanin.Because of difficulty in directly performing the lightning of melanin,it is difficult to make the skin become white in a short time (seeJapanese Patent Application Laid-Open No. 2006-151943).

The metal generally keeps atomic hydrogen (single atom represented by H)on the surface or at the inside. In the metals, the palladium andmagnesium can keep much atomic hydrogen at the inside, and the nickeland platinum can keep atomic hydrogen on the surface. The atomichydrogen has the strong reduction effect. Thus, a nickel sponge having alarge surface area is industrially utilized for the hydrogenationreaction (see Japanese Patent Application Laid-Open No.H9-132536).

When alloyed metal storing hydrogen is utilized for the cosmetics, it isnecessary to liberate the hydrogen (meaning not only the molecularhydrogen but also the atomic hydrogen) from the metal. The palladium,nickel and platinum are not preferable in view of the safety, because ametal insoluble to water remains in the body after the hydrogen isgenerated from the palladium, nickel and platinum (see Japanese PatentApplication Laid-Open No. 2006-151943).

When reacting with water, the magnesium hydride (generally representedby MgH₂ the chemical formula, and having the non-constant H content 0 to2) can generate the molecular hydrogen based on the reaction formuladescribed below. However, it is required for the generation of molecularhydrogen to keep the high temperature not less than 80 C.° or to apply acatalyst, such as MgCl₂ or acid. The prior patent application appliesacid for generating hydrogen from MgH₂.

MgH₂+2H₂O→Mg(OH)₂+2H₂

As described above, the atomic hydrogen has the strong reduction power.However, it is difficult to take the metal alloy storing hydrogen in acell with keeping the hydrogen in the alloyed metal. Thus, only themolecular hydrogen is utilized for the cosmetics. Even if the cell cantake in such an alloyed metal with nanoparticulate form, a metal mayremain in the body. Such a remaining metal may be harmful to theorganism.

It is not reported about cosmetics, quasi-drug and medical product thatgenerate hydrogen and lead the hydrogen's effect by applying themolecular hydrogen and atomic hydrogen directly onto the skin.

SUMMARY

The present invention has an object to provide an external-usecomposition that is incorporated with a hydrogen storing metal or metalalloy which keeps hydrogen therein and which can generate the kepthydrogen.

The inventors in this application has performed the keen examination fora method directly applying the hydrogen onto the skin. The inventorshave focused on the utilization of metal or metal alloy storing thehydrogen, and has found that the magnesium hydride (MgH₂) can beutilized for applying the hydrogen onto the skin.

MgH₂ does not react with the oxygen in the air during a short time,which is different from Mg the metal. MgH₂ is micronized by repeatedcollision among particles thereto. Based on the collision speed andcollision frequency, it is possible to produce a particle having apredetermined size. It is further possible to produce a nanoparticlethat can pass the superficial skin.

In addition, the specific gravity of MgH₂ is about 1.7. Thus, when MgH₂is suspended in the glycerol whose specific gravity is 1.26, theparticles is precipitated and thus it is not possible to keep thehomogenous condition. The suspension including a precipitated materialis not preferable as the trade article, because the user needs stirringthe suspension when using it. The inventors in this application hasperformed the keen examination for manufacturing the homogenoussuspension. Then, the inventors have found that MgH₂ having the particlediameter not more than 2 μm can implement the high specific gravity, andfurther prevent the generation of precipitate during a long time in thesuspension, such as glycerol or Bayu (horse oil).

The inventors have further found that, when the metal alloy storinghydrogen is suspended and directly applied with homogenous smooth liquidsolution or creamy material onto the skin, the hydrogen is absorbed intothe skin. Furthermore, the inventors have found that the hydrogen isgenerated by the reaction with water included in the skin or generatedfrom the skin cell, and then the generated hydrogen is absorbed in thebody before dispersed into the air. Moreover, the inventors have foundthat the magnesium hydride becomes Mg(OH)₂ after reacting with water,and that the Mg(OH)₂ is easily absorbed and flowed out because it issoluble in water although the solubility is poor. Thus, the inventorshave additionally found that the utilization of magnesium hydride issafety because it causes no disorder on the skin, and then the inventorshave made the present invention. In other words, the present inventionis described below:

[1] the skin external-use composition incorporated with a fine particleof metal or metal alloy storing hydrogen;[2] the skin external-use composition according to [1], wherein the fineparticle of metal or metal alloy storing hydrogen is a fine particle ofmagnesium hydride storing atomic hydrogen;[3] the skin external-use composition according to [2], which isincorporated with a fine particle of magnesium hydride that can generatemolecular hydrogen without catalyst when applied to a skin;[4] the skin external-use composition according to [2], which isincorporated with a fine particle of magnesium hydride storing atomichydrogen that passes a superficial skin;[5] the skin external-use composition according to any one of [1]-[4],which is in a cream state or gel state;[6] the skin external-use composition according to any one of [1]-[5],which is utilized for whitening;[7] the skin external-use composition according to any one of [1]-[5],which is utilized for treating a disorder selected from a group ofinflammation, allergy, wound, burn injury and bruise;[8] the skin external-use composition according to any one of [1]-[7],which is selected from a group of cosmetics, massage supporting liquid,esthetic clinic supporting liquid, quasi-drug and medical product;[9] a homogenous composition that includes a fine particle of magnesiumhydride, wherein the fine particle of magnesium hydride is homogenouslysuspended in an anhydrous liquid;[10] The composition homogenously suspended in the anhydrous liquidaccording to [9] for manufacturing a liquid solution having a highdensity of dissolved molecular hydrogen;[11] the composition according to [9] or [10], wherein the anhydrousliquid is glycerol or oil;[12] a method for manufacturing a water liquid solution includinghydrogen, comprising applying the composition according to any one of[9]-[11] into a water liquid solution; and[13] the method according to [12], wherein the water liquid solution isa drink or cosmetics.

When the metal alloy storing hydrogen of the present invention isapplied to the skin, the hydrogen is generated and the generatedhydrogen leads the antioxidant effect, anti-inflammatory effect andantiallergic effect. As the magnesium hydride of the present inventioncan be kept and utilized with a homogenous suspension form for a longtime, the user does not need stirring it when using it. Therefore, it isconvenient. In addition, the water liquid solution dissolving thehydrogen can be made with a room temperature and a short time about 1minute, by adding the magnesium hydride into the water liquid solution.It will be utilized in a wider range, depending on user's idea.Furthermore, it can be utilized as the externally applied composition,such as a cream which is homogenous, smooth, malleable and comfortable.

The composition of the present invention generating the hydrogen caninhibit the skin aging with the antioxidant effect. In addition, when itis applied to the skin, it leads the whitening effect. Thus, it can beutilized as the whitening cosmetics. Furthermore, it can inhibit theinflammation and thus has the healing acceleration effect for wound orburn injury.

The above and further objects and features will more fully be apparentfrom the following detailed description with accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1A is a graph that shows a distribution of particle diameter ofMgH₂ particle before micronized.

FIG. 1B is a graph that shows a distribution of particle diameter ofMgH₂ particle after micronized.

FIG. 2 is a view that shows a melanin lighting effect of a compositionincorporated with magnesium hydride.

FIG. 3A is a view that shows a skin whitening effect of the compositionincorporated with magnesium hydride.

FIG. 3B is a view that shows a skin whitening effect of the compositionincorporated with magnesium hydride.

FIG. 3C is a view that shows a skin whitening effect of the compositionincorporated with magnesium hydride.

FIG. 4 is a view that shows an effect for wound of the compositionincorporated with magnesium hydride.

FIG. 5 is a view that shows an effect for burn injury of the compositionincorporated with magnesium hydride.

FIG. 6 is a view that shows an effect for bruise of the compositionincorporated with magnesium hydride.

FIG. 7 is a view that shows a measured result of hydrogen density in thecomposition incorporated with magnesium hydride.

DETAILED DESCRIPTION

The present invention is explained below in detail.

A composition of the present invention is a fine particle of metal ormetal alloy storing and keeping hydrogen. In the present invention, thehydrogen means atomic hydrogen and/or molecular hydrogen.

The molecular hydrogen is generated from the metal or metal alloystoring the hydrogen, when the suspension including the hydrogen storingmetal or metal alloy keeping the hydrogen is directly contacted with theskin. Thus, the generated hydrogen is absorbed through the skin into theorganism, without dispersing outside the organism. It is known that themolecular hydrogen is dispersed and taken into the cell through the skinsurface. In addition, it is known that a fine particle metal is takeninto the dermal cell through the superficial skin. Therefore, the fineparticle metal storing the hydrogen can be taken into the cell withmaintaining the stored hydrogen, and generate the hydrogen in the cell.The hydrogen is stored, as the atomic hydrogen, by the fine particle ofmetal or metal alloy. The generated hydrogen may affect on the organismnot only as the atomic hydrogen but also as the formed molecularhydrogen. Both of the atomic hydrogen and molecular hydrogen can leadthe reduction effect in the organism. Especially, the atomic hydrogenhas the stronger reduction power. Thus, it is preferable to make theatomic hydrogen work in the organism.

Magnesium (Mg), titanium (Ti), vanadium (V), lanthanum (La) and the likecan be utilized as the metal storing the hydrogen. The hydrogen storingmetal or metal alloy in the present invention includes the above metalsand their alloyed metals that can store the hydrogen by becoming thehydrides combined with the hydrogen. Among them, the magnesium or itsalloyed metal is preferable because it hardly remains in the skin andthen it is flowed out. A metal compound storing the hydrogen is calledas a hydrogenated metal compound. For example, the magnesium storing thehydrogen is called as a magnesium hydride (MgH₂).

When the magnesium hydride is utilized, it reacts with water coming fromthe inside of skin, and generates the molecular hydrogen and theremaining of it becomes Mg(OH)₂. Thus, it is safety. As the Mg(OH)₂ ishardly but absolutely soluble in water, it does not remain in the skin.Therefore, it is harmless to the organism because it is flowed out tothe organism. The water coming from the inside of skin is moistureinternally kept by the skin, moisture generated by the metabolism, sweator the like.

When the fine particle is the magnesium hydride of atomic hydrogenstoring metal or metal alloy, the absorption of atomic hydrogen (H)leads the stronger reduction power by directly passing the magnesiumhydride through the superficial skin. Then, the atomic hydrogengenerated from MgH₂ reduces a contacted molecule, such as melanin(represented by X in the chemical formula described below, although itis not limited to the melanin).

MgH₂+2X→Mg+2H+2X→Mg+2XH

The remaining Mg reacts with H₂O and becomes Mg(OH)₂. Therefore, it isharmless because it does not remain in the cell as described above.

The fine particle of hydrogen storing metal or metal alloy according tothe present invention has the mean particle diameter 0.5 μm-10 μm.Preferably, it has the mean particle diameter 1 μm-5 μm. Furtherpreferably, it has the mean particle diameter 1 μm-3 μm.

Moreover, it is also possible to further micronize (nano-technique) thefine particle and to utilize the nanoparticle having the nanometer size.The nanoparticle has the mean particle diameter 5-500 nm. Preferably, ithas the mean particle diameter 10-100 nm. The nanoparticle having thediameter not more than 100 nm can pass the superficial skin of organismand can reach the dermis. In addition, the cell has the property oftaking the nanoparticle into it. For example, when the magnesium hydridewith nano size is taken into the cell, it emits the hydrogen in the celland leads the reduction effect. When the magnesium hydride reacts withwater, Mg(OH)₂ is formed as the coating. Thus, it reaches the dermis instable, relatively. Although Mg(OH)₂ is hardly soluble, the wholeparticle size gradually becomes smaller as it is gradually solved.Hence, if the magnesium hydride is a fine particle having the size thatavoids it from reaching the dermis through the skin, the magnesiumhydride can be micronized during passing the skin and can reach thedermis. Therefore, even if a fine particle having a size larger than thenano-size is applied to the skin, the fine particle can be graduallymicronized, pass the skin and reach the dermis.

When fine particles having different particle diameters are incorporatedfor different aims, it is possible to work both effects of thesedifferent fine particles. When a fine particle having a larger size isincorporated, it generates the hydrogen more slowly. When a fineparticle having a smaller size is incorporated, it generates thehydrogen more rapidly due to the larger surface area. Therefore, whenboth of smaller fine particle and larger fine particle are incorporated,it is possible to generate the hydrogen not only rapidly but also for along time.

The hydrogen storing metal or metal alloy can be manufactured by bindingthe hydrogen to the metal. Thus, it can be manufactured by theconventional known technique. For example, a pressure is applied on thecondition including the metal and hydrogen, for manufacturing it. Theobtained hydrogen storing metal or metal alloy may be micronized by thepowder collision or the like.

The specific gravity of MgH₂ is about 1.7. Thus, when MgH₂ having thelarge particle diameter, e.g., the mean particle diameter not less thantens μm, is suspended in the glycerol having the specific gravity 1.26,the particle is precipitated and it is difficult to keep the homogenouscondition. It is not preferable to sell the suspension including theprecipitated material as the product, because the user needs stirringwhen using it. However, when MgH₂ having the mean particle diameter notmore than 2 μm is suspended in the glycerol or the oil, such as horseoil, the MgH₂ is not precipitated for a long time and it is possible tokeep the homogenous suspension. It is considered that the result is dueto the characteristics of fine particle which generates the property ofelectrically repelling the particles to each other by the charge ofelectron.

When MgH₂ is suspended in the liquid medium, such as glycerol or oil, tomake the homogenous suspension of MgH₂ and the suspension is added tothe cosmetics, such as skin lotion, or the water liquid solution, suchas drink, the MgH₂ moves down to the lower portion. The molecularhydrogen generated at the lower portion is dissolved in the water liquidsolution while moving up to the upper portion. Thus, it is possible tomanufacture the hydrogen water with high density, for example, thesaturated hydrogen water in which the molecular hydrogens is saturated.On the other hand, if MgH₂ is directly added as the fine particle to thewater liquid solution, it reacts and generates the molecular hydrogen atthe upper portion of water liquid solution. Thus, the hydrogen is notdissolved into the water liquid solution, adequately. Therefore, it isnot possible to manufacture the water dissolving the hydrogen with highdensity.

Even in the case that the hydrogen storing alloyed metal of magnesiumhydride is not the fine particle, the water and MgH₂ particle will reactto each other. Then, because the generated Mg(OH)₂ is dissolved inwater, the magnesium hydride particle will become smaller and may passthe superficial skin. Different from the metal Mg, the MgH₂ does notreact during a short time with the oxygen in the air. Thus, the MgH₂particle repeatedly collide each other and then are micronized. It ispossible to manufacture a particle having the desired size, on the basisof the collision speed and collision frequency. It is also possible tomanufacture a fine particle that can pass the superficial skin. Forexample, it is possible to further micronize the fine particle of MgH₂by a method, in which the fine particle is put into an airtightcontainer with the inert gas (e.g., nitrogen) as the carrier gas andwhich causes the collision of particles to each other or the collisionto the wall surface. It is possible to obtain the fine particle of MgH₂having the desired size, by controlling the pressure of carrier gasdirected in the circumferential direction, the flow amount thereof, andthe added amount of MgH₂ powder, at that time. Among the MgH₂ fineparticles having the size not more than the desired particle diameter,the fine particle having the smaller particle diameter moves closer tothe center portion by the centrifugal force based on its own apparentspecific gravity. Then, it is accompanied by the carrier gas and flowedout of the system. In other words, the energy of motion is applied bythe carrier gas to the target substance to be micronized for moving itin the circumferential direction, the particles of target substance arecollided with each other, with wall surfaces or with obstacles by thegas flow becoming the eddy flow at any portions, and thus it is possibleto further micronize the fine particle of hydrogen storing metal ormetal alloy. In addition, it is possible to utilize the wet bead millfor micronizing the magnesium hydride. For example, the particle ofmagnesium hydride is mixed with oil, the mixture is put into the beadmill, and then the particle of magnesium hydride is made to have themean particle diameter about 1 μm.

It should be noted that the micronizing method of magnesium hydridedescribed above is an example, and the present invention is not limitedto this example.

The fine particle of hydrogen storing metal or metal alloy can be storedas the powder of fine particle, and can be utilized as the compositionby mixed with other reagent when needed. In addition, it can be storedby suspended in the anhydrous liquid, such as glycerol or oil, and canbe utilized as the composition by mixed with other reagent when needed.It is possible as the oil to select the animal oil, such as horse oil(Bayu), whale oil (Geiyu), lanolin oil (Yoyu) and squalene oil (Sameyu),and the vegetable oil, such as jojoba oil, olive oil, coconut oil andcamellia oil (Tsubaki oil). Furthermore, it is possible to select theoil and fat, such as shea butter. In addition, the hydrogen storingmetal or metal alloy can be stored while the creamy form or gel typeform is kept. It should be noted that the oil described above is notlimited to the nature oil, and it is possible to select the artificiallysynthesized organic compound or the like as the oil.

The metal alloy storing the hydrogen can generate the atomic hydrogen,even without the catalyst. Although the atomic hydrogen itself cannotpass the skin, it can pass the skin as the fine particle form of MgH₂.Then, the fine particle generates the atomic hydrogen in the cell, andthe reduction effect is implemented. The generated atomic hydrogen mayform the molecular hydrogen, and the molecular hydrogen has thereduction power weaker than the atomic hydrogen, but the formedmolecular hydrogen also implements the reduction effect in the organism.

The fine particle of metal alloy storing the hydrogen can beincorporated into the external-use composition. For example, theexternally applied composition is the skin external-use composition thatcan be applied to the skin.

The skin external-use composition has the antioxidant effect, canimplement lighting of melanin, and has the whitening effect. Thus, itcan be utilized as the whitening composition. Furthermore, it can beutilized as the composition for treatment against the inflammationdisease of skin and the allergy disease treatment of skin. It canaccelerate the healing of wound, burn injury, bruise or the like,because preventing the inflammation. The inflammation disease describedabove includes an inflammation disease caused by staphylococcus aureusbacteria, alveolar pyorrhea bacteria or the like, and an inflammationdisease caused by wound, scratch injury, burn injury, bruise or thelike. The allergy disease described above includes the atopicdermatitis, pollen disease, and the like. In addition, it is possiblewith the antiallergic effect or the like to prevent itching. Moreover,the skin external-use composition described above has the anti-agingeffect.

The present invention includes the skin external-use drug or skincosmetics having the effects described above, in which the above skinexternal-use composition is incorporated. Furthermore, the presentinvention includes the massage supporting liquid, such as massage oil,the esthetic clinic (total beauty technique, such as whitening)supporting liquid, the quasi-drug, the medical product, and the like, inwhich the above skin external-use composition is incorporated. When theabove massage supporting liquid in which the skin external-usecomposition is incorporated is applied to skin and then the massage isgiven, the muscle pain and stiff shoulder can be reduced.

It is possible to utilize the common procedure for manufacturing thecosmetics, medical goods, massage supporting liquid, esthetic clinicsupporting liquid, quasi-drug, medical product and the like, whichinclude the skin external-use composition of the present invention.Thus, it is possible to manufacture the basic cosmetics, such as skinlotion, milky lotion, moisturizer cream, cleansing cream, massage cream,face wash cream, pack and beauty essence, the bath cosmetics, such asbath agents, the makeup cosmetics, such as foundation, lipstick, mascaraand eye shadow, the special purpose cosmetics, such as sunscreen, theafter-shave lotion, the body soap, and the like. It is preferable tomake these products in the cream form or gel form. In addition, othervarious components may be incorporated. For example, it is possible forthe cosmetics to incorporate oil, surfactants, humectants, thickener,preservatives, antioxidants, ultraviolet absorbers, ultravioletscattering agent, flavors, dyes, pigments, bees wax or the like. As theoil, it is possible to utilize the animal oil, such as horse oil andwhale oil, the vegetable oil, such as jojoba oil and coconut oil, thefish oil, the bird oil and the like. The metal or metal alloy storingthe hydrogen of the present invention takes time to generate thehydrogen in the condition of strong alkali whose pH is not less than 11.Thus, it is preferable to select the pH of weak alkali, neutral oracidic, for the above composition or the cosmetics, medical goods,massage supporting liquid, esthetic clinic supporting liquid andquasi-drug which include the above composition. Particularly, the pHshould be less than 11. Preferably, the pH should be less than and closeto 10. However, it is not necessary to consider the pH change after thegeneration of hydrogen. For example, it is not required to prepare thesolid acid or the like to neutralize.

When the magnesium hydride is suspended and applied with homogenoussmooth liquid solution or creamy material directly onto the skin, thehydrogen is absorbed in the skin. The magnesium hydride reacts withwater included in the skin or generated from the skin cell, to generatethe hydrogen, and the generated hydrogen is absorbed in the organismsthrough the skin before dispersing into the air. After reacting withwater, the magnesium hydride becomes the Mg(OH)₂. Although hardly, theMg(OH)₂ is water soluble. Thus, it is easily absorbed or flowed out.Therefore, it is safety because no disorder is caused on the skin.

When the fine particle is utilized, it is possible to obtain thestronger whitening effect and stronger antioxidant effect. A particlebecomes smaller, as reacting with water, and then becomes the fineparticle.

For example, in the case that the composition of the present inventionis utilized for the massage supporting liquid or esthetic clinicsupporting liquid, the 1-5% (wt/vol) of MgH₂ is suspended into the oil,such as horse oil, in order to apply it on the skin at the time when themassage or esthetic clinic is started. The amount of MgH₂ may be changedadequately in consideration of the personal tolerance or the duration ofthe effect.

In addition, it is possible to manufacture the cream entrapping the MgH₂by suspending the MgH₂ into the heated mixture of oil, such as jojobaoil, and bee wax, and then by cooling the suspension. The adjustment ofamount of bee wax can change the firmness of cream. In addition, theflavor can be added. It is further possible to utilize not only the oiland bee wax but also emulsifying wax, shea butter or the like.

For example, the medical products incorporated with the skinexternal-use composition of the present invention is a cosmetic facemask (face sheet, foundation, face pack sheet or the like), bandage orlibatape (adhesive tape) which include magnesium storing the hydrogen ofthe present invention. For example, the hydrogen storing magnesium isapplied to the fabric portion of the face mask or bandage. When the facemask or bandage is worn, the hydrogen storing magnesium contacts withthe skin, reacts with water of skin, and generates the hydrogen. Then,the hydrogen is taken into the skin cell. Water may be externallyapplied by the aerosol or the like, at that time.

The MgH₂ can generate the molecular hydrogen under the room temperatureor body temperature, even without the catalyst. Therefore, the catalystis not necessary for generating the hydrogen by the fine particle ofhydrogen storing metal or metal alloy according to the presentinvention.

When added dropwise to the water liquid solution, such as skin lotion,in order to mix, the homogenous suspension with the fine particle ofmagnesium hydride in the anhydrous liquid, such as glycerol or oil canbecome the liquid dissolving the molecular hydrogen with high densityunder the room temperature even without the catalyst. Furthermore, whenadded to the drink, such as coffee, tea, juice, miso soup, soup, milk,or liquor, the anhydrous liquid containing the fine particle ofmagnesium hydride generates the molecular hydrogen in the drink.Therefore, it is possible to obtain the drink dissolving the molecularhydrogen with high density. Furthermore, it is possible to intake themolecular hydrogen together with liquid, for the sake of the drink. Onlyby adding the magnesium hydride to the drink and keeping it under theroom temperature for 1 minute at that time, it is possible tomanufacture the drink in which the hydrogen is saturated.

The skin lotion containing saturated hydrogen can be utilized forcosmetics, such as skin beautification. The drink containing saturatedhydrogen also can be utilized as healthy food, functional food, specialhealth food, food supplement and the like which have antioxidant effect.

For example, when the magnesium hydride particle having the particlediameter 2 μm is suspended in the dehydrated glycerol to make the MgH₂become 3.3% (wt/vol), it is possible to manufacture the saturatedhydrogen water liquid solution by adding one drop of this suspension(about 50 μL) into 100 mL of skin lotion or drink. At that time, notless than 50% of generated hydrogen is dissolved in water. It does notcause the problem that the extra hydrogen gas brings the burning orexplosion.

Embodiment

Although the present invention is particularly explained with theembodiments described below, the present invention is not limited to theembodiments.

Embodiment 1 Manufacturing the Fine Particle of MgH₂

The particle of MgH₂ having the mean particle diameter 60 μm ismicronized to make the mean particle diameter become 2 μm, and thus thefine particle of MgH₂ is manufactured.

Furthermore, the fine particle of MgH₂ having the mean particle diameter2 μm is micronized to make the mean particle diameter become 10-100 nm,and thus the nanoparticle of MgH₂ is manufactured. In the followingembodiments, the term of particle diameter represents the mean particlediameter.

In addition, the particle of MgH₂ having the mean particle diameter 60μm is micronized by the wet beads mill, and thus the fine particle ofMgH₂ having the mean particle diameter 1.035 μm is manufactured.

FIG. 1A is a graph that shows a distribution of particle diameter ofMgH₂ particle before micronized. FIG. 1B is a graph that shows adistribution of particle diameter of MgH₂ particle after micronized. Thehorizontal axis represents the particle diameter of MgH₂ particle, andthe vertical axis represents the frequency. For example, when 1 kg ofMgH₂ particle having the mean particle diameter 60 μm is mixed with 4 kgof jojoba oil, put into the wet beads mill and processed with 1.5-2.5l/m flow rate as shown in FIG. 1A, it is possible to obtain the MgH₂particle having the mean particle diameter 1.035 μm as shown in FIG. 1B.

It should be noted that the utilized liquid is an example. Thus, it isalso possible to utilize the olive oil, horse oil or the like. When theolive oil is utilized, it is possible to obtain the MgH₂ particle havingthe mean particle diameter 1.34 μm. Hence, it is possible to obtain theMgH₂ particle having the size smaller by the wet beads mill than the drymethod described above.

Embodiment 2 The Lighting Effect for Melanin

After the melanin (Sigma-Aldrich) is dissolved in the weak alkali liquidsolution, the solution is neutralized by the dilute acetic acid and thenthe glycerol suspension containing 10% of MgH₂ having the particlediameter 2 μm is dropped to the neutralized solution. In addition, theglycerol suspension containing 10% of MgH₂ having the particle diameter2 μm is previously reacted with water, and then the reacted suspensionfrom which the hydrogen is emitted is added dropwise to the abovemelanin liquid solution, in order to prepare the control sample. Some ofthem are put on the microplate and the images are captured. FIG. 2 showsthe result. In FIG. 2, the image at the left-top shows the controlsample in which the MgH₂ previously reacted with water is added to themelanin liquid solution. The image at the right-top shows the melaninliquid solution treated with MgH₂. The image at the left-lower shows themelanin liquid solution treated with the hydrogen gas. The image at theright-lower shows the melanin liquid solution treated with MgH₂. Asshown in FIG. 2, the lighting of melanin is observed in the MgH₂treatment. On the other hand, the color change is not observed in thecontrol sample.

Embodiment 3 The Whitening Effect

Cream containing 10% (wt/vol) of MgH₂ having the particle diameter 2 μmis applied to the skin, and then the image is captured after 24 hours.The left image in FIG. 3A shows the skin condition before theapplication of cream. The right image in FIG. 3A shows the skincondition after the application of cream. The lower image in FIG. 3Ashows a position where the cream is applied. The arrow represents theapplied position of cream. The position becomes whiter than the areaaround the position.

FIG. 3B shows another experimental result, in which cream containing 10%(wt/vol) of MgH₂ having the particle diameter 2 μm is applied to theskin and then the image is captured after 24 hours. The top image inFIG. 3B shows the skin condition before the application of cream. Thelower image in FIG. 3B shows the skin condition after the application ofcream. As shown in each image of FIG. 3B, it is observed that thesunspot at the almost center portion is disappeared and whitened.

FIG. 3C shows another experimental result, in which cream containing 10%(wt/vol) of MgH₂ having the particle diameter 2 μm is applied to theskin once a day and then the image is captured after 1 week. The topimage in FIG. 3C shows the skin condition before the application ofcream. The lower image in FIG. 3C shows the skin condition after theapplication of cream. As shown in each image of FIG. 3C, it is observedthat the sunspot at the left-upper portion is disappeared and whitened.

Embodiment 4 The Effect for Wound

Some injuries caused by the scratch of cat become similar scars withoutmoving the positions. The left image in FIG. 4 is immediately after thecat scratches, and degrees of two injuries are similar to each other.Cream containing 1.4% (wt/vol) of MgH₂ having the particle diameter 2 μmis applied only to the upper portion. On the other hand, creamcontaining 10% (wt/vol: the number of moles is adjusted for MgH₂) ofMg(OH)₂, as the control sample, is applied to the lower portion. One dayafter the application, both portions are compared (right in FIG. 4). Notonly the difference of appearances shown in images but also otherdifference was observed. The injury at the upper portion did not causethe inflammation that is common for the cut injury and brings somethinglike fever. In addition, the scar at the upper portion after the healingwas disappeared earlier. Therefore, the differences were obvious.

Embodiment 5 The Effect for Burn Injury

Cream containing 1.4% (wt/vol) of MgH₂ having the particle diameter 2 μmis applied only to the center portion of blackened scar area due to theburn injury. Before the application (the center image in FIG. 5), thecenter portion is blackened at the most. However, it is observed thatonly the center portion is lightened after 1 day (the left image in FIG.5). The right image in FIG. 5 shows the applied area of MgH₂ cream.

Embodiment 6 The Effect for Bruise

The subject person bumped his upper arm to the door of car. Afterseveral hours, cream containing 1.4% (wt/vol) of MgH₂ having theparticle diameter 2 μm was applied to a portion of bumped area, 1 cm² ofskin, and then the bumped area is covered by an adhesive tape. After 1day, a photograph of the bruise area was taken. Only the area appliedwith MgH₂ was not blackened. Thus, the anti-inflammatory effect is shown(FIG. 6).

Embodiment 7 The Effect for Itching Due to the Mosquito Bite

(1) After bitten by a mosquito, the subject person sit for 5-8 minutesin the bath filled with water in which MgH₂ having the particle diameter60 μm is dissolved to generate the hydrogen. Then, the subject personfelt free from the itching (0.8-1 g of MgH₂ was applied into the bathfilled with 200 litter of water [40-41 C.°], and 5 minutes later, thesubject person sit in the bath).(2) After bitten by a mosquito, MgH₂ having the particle diameter 2 μmwas applied to the bitten area. Then, the subject person felt free fromthe itching.

These results indicate that the hydrogen storing metal has the effectfor treating the allergy.

Embodiment 8 The Treating for Athlete's Foot (Tinea Pedis)

A patient of athlete's foot is treated for ten months with the bath(prepared with the same method to the embodiment 7) in which MgH₂ havingthe particle diameter 60 μm is dissolved to generate the hydrogen (thepatient took the bath for 10-20 minutes, with 5-7 times once a week).Then, the athlete's foot was healed.

Embodiment 9 The Measurement of Hydrogen Density

After glycerol suspension containing the MgH₂ having the particlediameter 2 μm was added dropwise to 150 mL of water (pH 6.8), the addedwater was stirred soon. The hydrogen density was measured with thehydrogen electrode, and the temporal response was recorded by therecorder. The speed 2 cm/minute was utilized for the recorder. FIG. 7shows the chart. In the case that one drop of 10% MgH₂ was added, 100%saturation was observed in the liquid solution after 30 seconds (theleft chart in FIG. 7). In the case that one drop of 3.3% MgH₂ was added,60% saturation was observed in the liquid solution after 2 minutes (theright chart in FIG. 7).

INDUSTRIAL APPLICABILITY

It is possible to utilize the skin external-use composition that isincorporated with the hydrogen storing metal alloy and generates thehydrogen of the present invention, and utilize the cosmetics,quasi-drug, medical product and the like that are incorporated with theskin external-use composition, for the following purposes:

(1) they can be utilized as the cosmetics having the antioxidant effect,anti-inflammatory effect and antiallergic effect;(2) they can be utilized as the cream having anti-inflammation effect;(3) they can improve the inflammation portion;(4) they can show the antiallergic property based on the antioxidanteffect;(5) they can be utilized as the massage oil for reducing or preventingthe muscle pain;(6) they can be utilized as the cosmetics and the esthetic clinic'sliquid showing the anti-aging effect based on the antioxidant effect;(7) they can improve the blood flow and ameliorate the disease (stiffshoulder, oversensitive to cold);(8) they can show the analgesic effect(the pain is disappeared when theyare utilized as lip cream);(9) they can be utilized as the composition incorporated into the facialwashing liquid or facial washing powder (the composition is solved inwater to be the facial washing liquid). When the face is washed with theliquid, the skin's elasticity (anti-saccharification effect) isimproved;(10) they can be utilized for treating the severe alveolar pyorrhea andstomatitis;(11) they can be utilized for treating the acne/pimple; and(12) they can reduce the fatigue when applied to the eyelids(improvement effect for the dark circle).

As this invention may be embodied in several forms without departingfrom the spirit of essential characteristics thereof, the presentembodiments are therefore illustrative and not restrictive, since thescope of the invention is defined by the appended claims rather than bythe description preceding them, and all changes that fall within metesand bounds of the claims, or equivalence of such metes and boundsthereof are therefore intended to be embraced by the claims.

1-13. (canceled)
 14. A skin external-use composition incorporated with afine particle of metal or metal alloy storing hydrogen.
 15. The skinexternal-use composition according to claim 14, wherein the fineparticle of metal or metal alloy storing hydrogen is a fine particle ofmagnesium hydride storing atomic hydrogen.
 16. The skin external-usecomposition according to claim 15, which is incorporated with a fineparticle of magnesium hydride that can generate molecular hydrogenwithout catalyst when applied to a skin.
 17. The skin external-usecomposition according to claim 15, which is incorporated with a fineparticle of magnesium hydride storing atomic hydrogen that passes asuperficial skin.
 18. The skin external-use composition according toclaims 14, which is in a cream state or gel state.
 19. The skinexternal-use composition according to claims 14, which is utilized forwhitening.
 20. The skin external-use composition according to claims 14,which is utilized for treating a disorder selected from a group ofinflammation, allergy, wound, burn injury and bruise.
 21. The skinexternal-use composition according to claims 14, which is selected froma group of cosmetics, massage supporting liquid, esthetic clinicsupporting liquid, quasi-drug and medical product.
 22. A homogenouscomposition that includes a fine particle of magnesium hydride, whereinthe fine particle of magnesium hydride is homogenously suspended in ananhydrous liquid.
 23. The composition homogenously suspended in theanhydrous liquid according to claim 22 for manufacturing a liquidsolution having a high density of dissolved molecular hydrogen.
 24. Thecomposition according to claim 22, wherein the anhydrous liquid isglycerol or oil.
 25. A method for manufacturing a water liquid solutionincluding hydrogen, comprising applying the composition according toclaims 22 into a water liquid solution
 26. The method according to claim25, wherein the water liquid solution is a drink or cosmetics.